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Symbol
Name
ID 		Vegfa
vascular endothelial growth factor A
MGI:103178
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Retinal hemorrhage
Cerebral hemorrhage
Bruising susceptibility
Abnormal cardiovascular system morphology
Abnormal endocardium morphology
Mitral valve prolapse
Restrictive cardiomyopathy
Coronary artery atherosclerosis
Medial calcification of large arteries
Medial calcification of medium-sized arteries
Arterial stenosis
Premature occlusive vascular stenosis
Arteriosclerosis
Atherosclerosis
Accelerated atherosclerosis
Vascular dilatation
Abnormal cerebral vascular morphology
Stroke
Mitral stenosis
Elevated diastolic blood pressure
Elevated systolic blood pressure
Hypertension
Renovascular hypertension
Weak pulse
Intermittent claudication
Sudden cardiac death
Angina pectoris
Congestive heart failure
Abnormality of the hepatic vasculature
Lymphadenopathy
Splenomegaly
Hepatosplenomegaly
Telangiectasia of the skin
Disease(s) Associated with VEGFA
chronic myeloid leukemia
Graves' disease
multiple myeloma
pre-eclampsia
pseudoxanthoma elasticum

Mouse Phenotypes
cardiovascular system phenotype
abnormal blood vessel morphology
abnormal arteriole morphology
abnormal artery morphology
abnormal dorsal aorta morphology
persistent ductus caroticus
persistent right dorsal aorta
abnormal pharyngeal arch artery morphology
abnormal fourth pharyngeal arch artery morphology
abnormal sixth pharyngeal arch artery morphology
abnormal third pharyngeal arch artery morphology
poor arterial differentiation
decreased pulmonary endothelial cell surface
aorta pulmonary collateral arteries
pulmonary trunk hypoplasia
retroesophageal right subclavian artery
cervical aortic arch
interrupted aortic arch, type b
right aortic arch
double aortic arch
abnormal carotid artery morphology
abnormal coronary artery morphology
abnormal kidney arterial blood vessel morphology
abnormal kidney afferent arteriole morphology
abnormal kidney interlobular artery morphology
abnormal kidney efferent arteriole morphology
abnormal glomerular capillary endothelium morphology
absent glomerular endothelium fenestra
decreased vascular endothelial cell number
abnormal capillary morphology
abnormal capillary branching pattern
decreased capillary density
abnormal glomerular capillary morphology
decreased glomerular capillary number
dilated glomerular capillary
abnormal peritubular capillary morphology
dilated capillary
increased capillary tortuosity
abnormal brain vasculature morphology
abnormal retina vasculature morphology
abnormal kidney vasculature morphology
abnormal lung vasculature morphology
abnormal pericyte morphology
abnormal placenta vasculature
abnormal vascular development
abnormal angiogenesis
abnormal vascular regression
abnormal vascular branching morphogenesis
abnormal vitelline vein morphology
decreased angiogenesis
abnormal vascular endothelial cell differentiation
abnormal vitelline vasculature morphology
abnormal coronary vein morphology
abnormal venule morphology
abnormal myocardial fiber morphology
increased myocardial fiber size
myocardial fiber degeneration
abnormal myocardial trabeculae morphology
thin ventricle myocardium compact layer
myocardium necrosis
abnormal cardiac epithelial to mesenchymal transition
abnormal cardiac outflow tract development
abnormal truncus arteriosus septation
persistent truncus arteriosus
abnormal heart development
delayed heart development
abnormal heart morphology
abnormal coronary vessel morphology
overriding aortic valve
abnormal endocardium morphology
abnormal heart septum morphology
abnormal interventricular septum morphology
ventricular septal defect
enlarged heart
thin ventricular wall
abnormal cardiovascular system physiology
abnormal blood circulation
cardiac ischemia
abnormal pulmonary circulation
hemorrhage
retina hemorrhage
heart hemorrhage
kidney hemorrhage
decreased cardiac muscle contractility
abnormal cardiac muscle relaxation
decreased left ventricle systolic pressure
decreased heart rate
irregular heartbeat
abnormal impulse conducting system conduction
prolonged QRS complex duration
prolonged QT interval
abnormal ST segment
abnormal T wave
increased vascular permeability
Availability Mouse Genotype
Vegfatm1.1Nagy/Vegfatm1.1Nagy
Vegfatm1Dco/Vegfatm1Dco
Vegfatm1Pec/Vegfatm1Pec
Vegfatm2.1Nagy/Vegfatm2.1Nagy
Vegfatm2Pec/Vegfatm2Pec
Vegfatm4Pec/Vegfatm4Pec
Vegfatm1Dco/Vegfa+
Vegfatm1Gne/Vegfa+
Vegfatm2.1Nagy/Vegfa+
Tg(KRT14-Vegfa)3Dtm/0
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-Vegfa)1Kesh/0
Tg(Neph1-Vegfa)1Seq/0
Vegfatm2Gne/Vegfatm2Gne
Tg(Nphs1-cre)1Seq/0  (conditional)
Vegfatm2Gne/Vegfatm2Gne
Tg(Prrx1-cre)1Cjt/0  (conditional)
Vegfatm2Gne/Vegfatm2Gne
Tg(SFTPC-cre)#Mliu/0  (conditional)
Vegfatm2Gne/Vegfatm2Gne
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Vegfatm2Gne/Vegfatm2Gne
Tg(Tnnt2-cre)5Blh/0  (conditional)		 *
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0  (conditional)
Vegfatm2Gne/Vegfatm2Gne
E2f1Tg(Wnt1-cre)2Sor/E2f1+  (conditional)
Vegfatm2Gne/Vegfa+
Tg(Nphs1-cre)1Seq/0  (conditional)
Vegfatm2Gne/Vegfa+
Tg(Nes-cre)1Kln/0  (conditional)
Vegfatm2Gne/Vegfa+
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Vegfatm2Gne/Vegfatm2.1Nagy
Tg(Nes-cre)1Kln/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory